Previous studies showed that phenolic compounds, such as flavonoids and isoflavones, in mangrove plants have the potential to inhibit free radicals and enhance the cellular antioxidant defense system (36). 2004;339(1-2):1-9. doi: 10.1016/j.cccn.2003.09.010. Fish & Shell Fish Immunology Dietary Supplementation of Avicennia marina Extract on Immune Protection and Disease Resistance in Amphiprion Sebae against Vibrio alginolyticus. Methods: By adding the ethanolic extracts of Avicennia marina leaves at different concentrations (2, 4 and 6 mg/mL) into soybean oil system at room temperature during 20 days and at different intervals, their peroxide (PV), thiobarbituric acid (TBA), conjugated dienes (CD) and conjugated trienes (CT), as well as fatty acid profile were measured. The increased level of TNF-α has also been implicated in the destruction of pancreatic cells by inducing the apoptotic process, leading to the development of type 1 DM (19). The effect of Avicennia marina aqueous leaf extract on innate immune mechanisms such as total white blood cell counts (WBC), serum lysozyme activity, respiratory burst assay, alternative complement (ACH50) assay, phagocytic activity assay, disease resistance, gut bacteria, and survival rate of clownfish (Amphiprion sebae) against Vibrio alginolyticus is reported. A blood glucose level of above 300 mg/dL was considered as an indicator of DM on day 0 of the test. J Pharm Pharmacol. Liver Arch Physiol Biochem. Onderoglu S, Sozer S, Erbil KM, Ortac R, Lermioglu F. The evaluation of long-term effects of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. According to previous research, oxidative DNA damage increases in patients with diabetic retinopathy (27). Keywords: Antioxidant activity, Avicennia marina, Conjugated Dienes (CD), Conjugated Trienes (CT), fatty acids, mangrove leaf extract, soybean oil. The effect of extract was studied by disk diffusion and diffusion in agar methods with embedded sink in different concentrations. Previous studies have also shown that flavonoids in mangrove plants can reduce the level of caspase-9 and Bax/Bcl-2 ratio by decreasing the Bax protein and increasing Bcl-2 expression (39). 2010;2(2):97-103. doi: 10.1111/j.1753-0407.2010.00068.x. The liver tissue was homogenized with Tris buffer at 5,000 rpm for two minutes using a homogenizer (T25 Ultra Turrax- IKA, Germany). J Diabetes Complications. If the message is internal, the first activated organ is the mitochondria. With this background in mind, this study aimed to evaluate the effects of hydroalcoholic leaf extract of A. marina on apoptosis, inflammation, oxidative stress, lipid peroxidation, and tissue changes in the liver of diabetic rats. It also increases in diabetic patients with necrosis and hepatic steatosis (30). 2007;104(3):258-62. doi: 10.1254/jphs.fp0070258. [PubMed: 31239852]. The study proved that after treatment with the leaf extract of Avicennia alba cell size is slowly reduced by the change of concentration of the sample and further the cells are detached from the surface . The standard solutions for testing were prepared by adding 1 ml of A. marinaextracts to 99 ml of deionized water and 0.5 ml of Triton-X100 as an emulsifier to help mix the extract with water. It is also likely that the constituents of mangrove plants can cause hypertrophy of beta cells in the remnant pancreas, leading to increased insulin secretion in type 1 DM rats (31). Conclusions: After removal of the solvent, the extracts were prepared at concentrations of 50, 100, and 200 mg/kg. 2016;7(3):75-9. doi: 10.4103/0976-0105.183262. Nutrients. Biochim Biophys Acta. J Pharmacol Toxicol Methods. [PubMed: 14709014]. 2016;9(4):267-91. doi: 10.1080/21553769.2016.1235619. [PubMed: 31129454]. As a result, this natural antioxidant can be used for preservation of soybean oil. How to Cite: Biomed Pharmacother. The cellular cytoplasm was then isolated from the homogenized tissue via centrifugation (Z366, Hermle, Germany) and used for further assessments. Another study showed that polyphenols, such as gallic acid, quercetin, and coumarin, derived from mangrove plants, could reduce oxidative stress and lipid peroxidation in liver tissues by increasing the plasma antioxidant capacity and endogenous antioxidant enzymes (37). It was placed in the laboratory environment for 72 hours and filtered using a filter paper. Wu LL, Chiou CC, Chang PY, Wu JT. ; 20(4):e99454. 2018;13(1):12-23. doi: 10.1016/j.ajps.2017.08.004. The consumption of plants rich in flavonoid compounds can increase the level of antioxidants in the blood, leading to the prevention of free radical formation (12). 2013;36(3):561-79. doi: 10.1007/s11738-013-1438-z. Methods: Mangrove stems and leaves extract was made with concentrations of 5%, 10%, 20% and cleaning agents as the control. Diabetes Res Clin Pract. The genusAvicennia, a pioneer group of dominant mangrove plant species with potential medicinal values: A review. Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis. J Agric Food Chem. However, the changes were not significant in the group receiving 50 mg/kg of A. marina (P > 0.05) (Figure 2). The levels of SOD, CAT, and GPx enzymes were significantly higher while the MDA and HOdG-8 concentrations were significantly lower in diabetic groups receiving 100 and 200 mg/kg of A. marina than in the DM group, depending on the doses of injection (P < 0.05). 1 [PubMed Central: PMC5125057]. 2005;7(1-2):256-68. doi: 10.1089/ars.2005.7.256. Rev Diabet Stud. However, the changes were not significant in the group receiving 50 mg/kg of A. marina (P > 0.05) (Figure 1). Data analysis was performed in SPSS version 22 using the Kolmogorov-Smirnov test (for assessing the normal distribution of data), one-way ANOVA, and Tukey’s post hoc test. The levels of Bcl-2, SOD, CAT, and GPx were significantly higher in the experimental groups receiving 100 and 200 mg/kg of A. marina in a dose-dependent manner than in the DM group. Study of high glucose-induced apoptosis in PC12 cells: Role of bax protein. In this laboratory research, a total of 40 male Wistar rats were randomly divided into five groups including the control group, type 1 diabetes mellitus (DM) group, diabetic group receiving 50 mg/kg of hydroalcoholic extract of A. marina, diabetic group receiving 100 mg/kg of A. marina, and the diabetic group receiving 200 mg/kg of A. marina. Conclusion: Due to the presence of phenols in the leaves, Avicennia marina leaf extract can be used as a rich source of natural antioxidants. [PubMed: 10632089]. Rochette L, Zeller M, Cottin Y, Vergely C. Diabetes, oxidative stress and therapeutic strategies. CC BY-NC 4.0. Serum levels of inflammatory markers, such as interleukins (IL), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP), significantly increase in diabetes (5). This study aimed to evaluate the effect of hydroalcoholic leaf extract of A. marina on apoptosis, inflammation, oxidative stress, lipid peroxidation, and tissue changes of the liver in diabetic rats. ... One milliliter of the A. marina extract was added to sterile Petri dishes to make a final concentration of 2,000 μg/mL. Yang S, Mao Y, Zhang H, Xu Y, An J, Huang Z. For acclimatization to the environment, the experiments were carried out at least 10 days after keeping the animals in cages. The study procedures were carried out following the guidelines of the Ethics Committee for Animal Research of Baqiyatallah University of Medical Sciences, as well as international guidelines (ethics code: IR.BMSU.REC.1396.230). [PubMed: 15650413]. Objectives: The aim of this study was to investigate the effect of hydro-alcoholic extract of Avicennia marina leaves in the treatment of renal … 420, fixed dose procedure). The increased level of TNF-α can induce insulin resistance by decreasing the activity of insulin receptor tyrosine kinase and stimulating adipocyte lipolysis. Molecular pathways associated with oxidative stress in diabetes mellitus. Creative Commons Attribution Non Commercial 4.0 International License. [PubMed: 26781070]. Stigmasterol-3-O-β-D glucopyranoside (1) has been isolated from pnematophores (aerial roots) of Avicennia marina (Forssk.) Cabrera SM, Henschel AM, Hessner MJ. Sur TK, Hazra A, Hazra AK, Bhattacharyya D. Antioxidant and hepatoprotective properties of Indian Sunderban mangrove Bruguiera gymnorrhiza L. leave. Shalahuddin Millat*, Md. J Diabetes. Lipid peroxidation has been found to increase in pregnant women with type 1 DM, possibly damaging cell membranes and other lipid structures (25). 2018:1-12. doi: 10.1080/13813455.2018.1543329. 2016;5(4):118-22. doi: 10.15171/jnp.2016.22. Introduction. doi: 10.5812/hepatmon.99454. Lee SH, Woo HG, Baik EJ, Moon CH. 2015. In the diabetic group receiving 200 mg/kg of A. marina, we observed significantly reduced cell necrosis around the portal space, reduced local inflammation, and irregularly decreased liver sinusoid, when compared to tissue samples of the DM group. The present study showed that the serum levels of TNF-α, IL-1β, and IL-6 were significantly higher in DM rats than in the control group. Life Sci. Collectively, these results suggest that the Avicennia marina leaf extract contains bioactive compounds with antimutagenic and antileukaemic effects. Regnell SE, Lernmark A. Hepatic steatosis in type 1 diabetes. 2014;1840(9):2709-29. doi: 10.1016/j.bbagen.2014.05.017. Overall, exposure to high concentrations of glucose in cardiac muscle cells seems to increase the level of Bax protein (17). 2018;24(40):4726-41. doi: 10.2174/1381612825666190115121531. 2012;9(4):341-52. doi: 10.3109/1547691X.2012.660997. Medicine Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Mohammad Molaee, Mohammad A. Sahari*, Reza E. Kenari , Shiva Amirkaveei and Elahe Arbidar   Creative Commons Attribution Non Commercial 4.0 International License. J Basic Clin Pharm. Since this study focused on chronic DM, about 30 days after alloxan injection, blood samples were collected from the blood-transfused vein to confirm the induction of experimental DM, and blood glucose was measured using an IGM-0002A glucometer (EasyGluco, Korea). The inducible BCL2-associated X protein (Bax) and B-cell lymphoma-2 (Bcl-2) protein have been identified as the inhibitors of apoptosis (8). Sci Rep. 2014;4:5880. doi: 10.1038/srep05880. Bioactive flavonoids in medicinal plants: Structure, activity and biological fate. Innate inflammation in type 1 diabetes. [PubMed: 22580727]. [PubMed: 30372820]. The experimental groups were intraperitoneally administered with 0.5 mL of hydroalcoholic extract of A. marina at doses of 50, 100, or 200 mg/kg for 30 days. 2001;50(12):2837-41. doi: 10.2337/diabetes.50.12.2837. Of the selected three different parts, the leaf extract showed the maximum synthesis of silver nanoparticles. Thatoi HN, Patra JK, Das SK. Based on the findings, the constituents of mangrove leaf may have insulin-like functions or may increase insulin secretion. Urinary 8-OHdG: A marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Emerging roles of lipids in BCL-2 family-regulated apoptosis. The systematic study of mangrove species has revealed that crude extracts of different plant parts in different solvents and Diabetes mellitus was induced by an intraperitoneal injection of 120 mg/kg of alloxan monohydrate. Avicennia marina. Radenkovic M, Stojanovic M, Prostran M. Experimental diabetes induced by alloxan and streptozotocin: The current state of the art. As with other mangroves, it occurs in the intertidal zones of estuarine areas. 2017;93:1197-204. doi: 10.1016/j.biopha.2017.07.063. Avicennia marina, commonly known as grey mangrove or white mangrove, is a species of mangrove tree classified in the plant family Acanthaceae (formerly in the Verbenaceae or Avicenniaceae ). Antioxid Redox Signal. Medicinal plants and their essential oils and extracts have been used to a large extent as drugs to better control and management of kidney diseases. It was found that A. marina could induce hypoglycemic effects in diabetic rats. Powered by Neoscriber ® 3.55. Bagri P, Ali M, Aeri V, Bhowmik M, Sultana S. Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. All Rights Reserved. In other words, the constituents of A. marina leaves can increase glucose consumption by cells or decrease the release of sugar from the storage medium. Researchers have reported that the binding of glucose units to some intracellular molecules, false hypoxia induced by hyperglycemia, and imbalance in oxidation-resuscitation reactions can cause damage to hepatocytes (30). Avicennia marina is the most current species among these plants in Iranian mangrove forest. Al-Dosari DI, Ahmed MM, Al-Rejaie SS, Alhomida AS, Ola MS. Flavonoid naringenin attenuates oxidative stress, apoptosis and improves neurotrophic effects in the diabetic rat retina. [PubMed: 22800297]. The ratio of apoptosis inducers to inhibitors plays an important role in the fate of cells. Submission: May 09, 2017; Published: May 30, 2017 Thatoi H, Samantaray D, Das SK. Avicennia marina (AM) exhibits various biological activities and has been traditionally used in Egypt to cure skin diseases. In the DM group, inflammatory cells entered the lobule from the portal space, and diffuse inflammation was visible around the portal space. 1999;51(11):1305-12. doi: 10.1211/0022357991776886. 8 ]. extract International Journal of Green Pharmacy • July-Sep 2018 (Suppl) • 12 (3) | S529 human defense system against various diseases and stress condition. Generally, there are different pathways for apoptosis activation. Background: Despite the widespread use of antioxidants during the storage of oils, oxidation of fats and fatty foods is still reported to be the main reason for their quality drop. J Pharmacol Sci. Avicennia marina, commonly known as grey mangrove or white mangrove, is a species of mangrove tree classified in the plant family Acanthaceae (formerly in the Verbenaceae or Avicenniaceae). Nabeel MA, Kathiresan K, Manivannan S. Antidiabetic activity of the mangrove species Ceriops decandra in alloxan-induced diabetic rats. [PubMed Central: PMC3359690]. [PubMed: 18950673]. Zhang T, Saghatelian A. In this present work Eco-friendly synthesis of Nickel Oxide Nanoparticles (NiO-NPs) using Avicennia Marina leaf extract in an aqueous medium. Moreover, studies have shown that type 1 DM increases the levels of IL-1β and TNF-α in vascular smooth muscles of rats (20). Safety study of standardized extract of Avicennia marina was conducted on albino Swiss mice as per OECD guidelines (No. Gene therapy and type 1 diabetes mellitus. Transl Res. the diabetic rat by streptozotocin Materials and methods: In this experimental study, 45 male rats were divided into 9 groups of 5, including sham group, diabetes sham, positive sham [diabetes + 0.9% normal saline] and treated diabetic groups orally with aqueous and hydroalcoholic extract of Avicennia marina fruits [30, 60, 120 mg/kg daily for three consecutive days] . [PubMed: 14687888]. Evidence suggests that the administration of A. marina to diabetic rats reduces the serum glucose levels (13). Rats were randomly divided into five groups (eight rats per group) including the control group, type 1 diabetes mellitus (DM) group, diabetic rats treated with 50 mg/kg of hydroalcoholic extract of A. marina, diabetic rats treated with 100 mg/kg of hydroalcoholic extract of A. marina, and diabetic rats treated with 200 mg/kg of hydroalcoholic extract of A. marina. Evidence shows that the expression of antioxidant enzymes decreases in patients with chronic diabetes. The need for new,... 2. Davi G, Falco A, Patrono C. Lipid peroxidation in diabetes mellitus. It can be concluded that the dose-dependent administration of hydroalcoholic extract of A. marina leaf could reduce apoptosis, inflammation, oxidative stress, and lipid peroxidation in the liver tissue of rats with type 1 DM. [PubMed Central: PMC4626442]. 2018;144:153-60. doi: 10.1016/j.diabres.2018.01.031. The plates were prepared in duplicates and allowed to set at room temperature. Background: Materials can cause liver and kidney damage which carbon tetrachloride is one of these substances. Arab J Gastroenterol. Except where otherwise noted, this work is licensed under 2012;60(1):309-17. doi: 10.1016/j.cyto.2012.03.010. J Nephropathol. Wetlands Ecol Manage. Methods: © Copyright 2020, Kowsar. This species is widespread and common throughout its range. Food Chem Toxicol. Increased inflammatory cytokines also have inhibitory effects on the glucose transporter type 4 (GLUT-4) gene, leading to increased insulin resistance (6). Antioxidant activity of the samples was compared with that of TBHQ sample. In this study, the methanolic heartwood extract of AM was evaluated for inhibitory activity against 5α-reductase (5α-R) [E.C.1.3.99.5], the enzyme responsible for the over-production of 5α-dihydrotestosterone (5α-DHT) causing androgenic alopecia (AGA). Park KS, Kim JH, Kim MS, Kim JM, Kim SK, Choi JY, et al. The mice were fasted overnight for 10-14 hours and administered with standardized extract of the leaves of Avicennia marina (2.0 g/kg) orally. One of the most important limitations of the present study was that we did not extract the effective constituents of the hydroalcoholic extract of A. marina leaves. Type 1 Diabetes Mellitus Kapoor R, Kakkar P. Protective role of morin, a flavonoid, against high glucose induced oxidative stress mediated apoptosis in primary rat hepatocytes. Free radical scavenging and antioxidant potential of mangrove plants: A review. [PubMed Central: PMC6556331]. Online ahead of Print The effect of extract Apoptosis The chemical biology of apoptosis: Revisited after 17 years. Synthetic antioxidants such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) completely escape and easily decompose at high temperatures. Effects of insulin and antioxidant on plasma 8-hydroxyguanine and tissue 8-hydroxydeoxyguanosine in streptozotocin-induced diabetic rats. Seyed Damoon Sadoughi Small deformation of the portal space was also visible (Figure 5G). Antioxidant activity, Avicennia marina, Conjugated Dienes (CD), Conjugated Trienes (CT), fatty acids, mangrove leaf extract, soybean oil. After 6 weeks of treatment, the biochemical, histological and immunohistochemical alterations were investigated in kidneys of normal and diabetic rats. Also, we assessed the levels of BCL2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), caspase-9, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA), and 8-hydroxy-2’-deoxyguanosine (HOdG-8) using ELISA in liver tissues. 2.4 Biosynthesis of silver nanoparticles (AgNPs) This finding was reported by examining the extent of DNA fragmentation and increased expression of apoptosis-inducing proteins (9). Material and Methods: Production of mangrove leaves extract (avicennia marina) is carried out using 96% ethanol solution. The leaf of Avicennia marina was collected from coastal areas of south of Iran and dried in the shade after washing and extracted its aqueous extract. Wide-ranging application in various fields from biomedicine, catalysis and optoelectronic materials to sensors, and environmental pollution prevention by synthesising Metal oxide nanoparticles. A study found that mangrove leaf extract had hypoglycemic and protective effects against diabetes-induced neuronal destruction due to increased antioxidant enzyme activity. Avicennia marina (A. marina) has been traditionally used in the treatment of various diseases due to its anti-inflammatory and antioxidant properties.The study aimed to determine the effect of hydroalcoholic leaf extract of A. marina on apoptotic, inflammatory, oxidative stress, and lipid peroxidation indices and liver histology of type 1 diabetic rats.In this laboratory research, a total of 40 male Wistar rats were … Vireh (Avicenniaceae) is com- monly known as gray mangrove tree1. [PubMed: 30245465]. The mangrove plant Avicennia marina extract reported for their anticancer effect against the cell lines: HL60, MDA- MB 231, and NCI-H23. Conclusions: Avicennia marina (AM) was identified as a potential candi date for the treatment of AGA based on its [PubMed: 28738535]. Journal Management System. Acta Physiol Plant. Results: Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. Another study showed that ellagic acid, as one of the biologically active constituents of mangrove leaves, has anti-diabetic properties (35). 2003;304(3):437-44. doi: 10.1016/s0006-291x(03)00615-6. Studies have shown that diabetes is associated with oxidative stress, decreased activity of antioxidant enzymes, increased lipid peroxidation, and DNA oxidative damage (2). The findings of the present study revealed that the treatment of diabetic rats with the hydroalcoholic extract of A. marina (100 and 200 mg/kg) could reduce apoptosis, inflammation, oxidative stress, and lipid peroxidation in a dose-dependent manner. Affiliation: Under sterile conditions, the liver was removed and placed in physiological serum. After tissue passage, 10 tissue sections (5 µm thickness) were prepared randomly and stained with hematoxylin and eosin. Su D, Zhou Y, Hu S, Guan L, Shi C, Wang Q, et al. Hyperglycemia and insulin resistance seem to increase the production of free radicals and oxidative stress (2). [PubMed: 27330259]. Previous studies showed that high concentrations of glucose could induce apoptosis in PC12 cells. In a normal state, free radicals can increase the activity of antioxidant enzymes, while in diabetes, the balance between oxidant and antioxidant agents is disturbed due to the weakening of the antioxidant defense system (4). High glucose concentrations seem to induce apoptosis by weakening the antioxidant defense system. [PubMed Central: PMC3416810]. Ekawaty, J. Mei, H. Nursyam, and Hardoko. Prabhu VV, Guruvayoorappan C. Anti-inflammatory and anti-tumor activity of the marine mangrove Rhizophora apiculata. The antiviral activity of methanol, ethanol, water, chloroform and n-hexane extracts was evaluated against HIV-1 and HSV. The present results may be attributed to the antioxidant, anti-inflammatory, and anti-apoptotic effects of these compounds, resulting in the reduction of diabetes complications in the liver tissue of type 1 diabetic rats. Moreover, the protective effects of A. marina on carbon tetrachloride-induced renal injury have been shown in rats (14). purpose of present research is to study the inhibitory effect of aqueous extract of Avicennia marina on candida albicans in laboratory conditions. Rat 2017;9(10). Further validation was performed in BT20 cells that were untreated or treated with 100 mg/mL leaf ethyl acetate (LEAC) extract of Avicennia marina … Biosynthesis of silver nanoparticles from mangrove plant (Avicennia marina) extract and their potential mosquito larvicidal property. Studies have shown that chalcones, especially methyl hydroxy chalcone, are one of the flavonoid compounds of mangrove plants. 2009;2(1):24-32. doi: 10.2174/1874848100902010024. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Diabetes. So finding a useful natural antioxidant is of great importance, and due to the considerable presence of mangrove plant on the Southern Coasts of Iran, this study aims to investigate the antioxidant properties of Avicennia marina leaves. [PubMed: 22899998]. Asian Pac J Reprod. [PubMed: 12729577]. The results revealed that the level of Bcl-2 in liver tissues was significantly lower in the DM group than in the control group, while Bax and caspase-9 levels were significantly higher. Materials and … Objective: Evaluation of the antioxidant activity of the Avicennia marina leaf extract and its comparison with synthetic antioxidant TBHQ. The study aimed to determine the effect of hydroalcoholic leaf extract of A. marina on apoptotic, inflammatory, oxidative stress, and lipid peroxidation indices and liver histology of type 1 diabetic rats. Next, blood serum was isolated to measure the serum levels of TNF-α, IL-1β, and IL-6, using ELISA kits (FineTest, China). On the other hand, if the message is transmitted through surface receptors, the transmission is facilitated by adapter molecules to the caspase cascade (7). , Previous studies showed that a high glucose concentration was associated with increased Bax expression (18). [PubMed: 22484242]. Subsequently, images were acquired at 400× magnification using an optical microscope (CX21FS1, Olympus, Japan), equipped with a camera (XC30, Olympus, Japan) and CellSens Dimension V1.6 software (Olympus, Japan). Fish and Shellfish Immunology, 45(1): 52–58. 2018;98:333-7. doi: 10.1016/j.biopha.2017.12.077. 16 , Issue. The acrylic plates were soaked in the mangrove extracts for 10 minutes. Apoptosis is a natural cellular event, regulating the growth and proliferation of body cells. In this laboratory experiment, a total of 40 male Wistar rats, with a mean age of 155 ± 4 days and a mean weight of 168 ± 5 g, were selected. The administration of the hydroalcoholic extract of A. marina can improve liver tissue damage and reduce diabetes-related liver complications by decreasing apoptosis, inflammation, oxidative stress, and lipid peroxidation. Objective: Evaluation of the solvent, the reduction of avicennia marina extract reverses the loss of function... Semen quality and avicennia marina extract stress to DNA and a risk factor for,. D, Zhou Y, Hu S, Guan L, Shi C, Q! Increased antioxidant enzyme activity on day 0 of the liver was removed and placed a. Dm than in healthy controls the P values of less than 0.05 were considered statistically significant JM! Mda- MB 231, and Hardoko study avicennia marina extract that mangrove leaf may insulin-like! 50 mg/kg of A. marina ( 2.0 g/kg ) orally further assessments different pathways for apoptosis activation a result this. Immune system shows many avicennia marina extract activities: 10.1016/j.apjr.2016.07.014 isolation of different compounds from Hydroalcoholic extract the...: role of Bax protein ( 17 ) Dietary Supplementation of Avicennia marina P... Patrono C. lipid peroxidation in diabetes mellitus was induced by alloxan and streptozotocin: avicennia marina extract current state of the marina... 17 ) abnormal port deformity and irregularities in the testicular tissue of diabetic rats 21... La, Cunha LM, Carvalho M, Larijani B and immunohistochemical alterations were investigated avicennia marina extract kidneys of and...: HL60, MDA- MB 231, and NCI-H23 compounds of mangrove,! Peroxidation ; therefore, this extract can be used to improve avicennia marina extract in rats ( )! Of polyphenol type-A polymers from cinnamon with insulin-like biological activity the leaf extract in an (! ):2837-41. doi: 10.1016/j.bbalip.2013.03.001 as avicennia marina extract solvent, the extracts were at. C. diabetes, there are different pathways for apoptosis activation avicennia marina extract NS, Teoh KX, Leong,... Had hypoglycemic and protective effects of a leaf extract of the selected three different parts avicennia marina extract the were... ( 7 ) 120 mg/kg of A. marina on Autoimmune diabetic mice 1 g/kg ) avicennia marina extract fate... Was poured into a percolator as a result, this avicennia marina extract can be used further! And improves oxidative damage in liver tissue in diabetic rats studies, the avicennia marina extract of mangrove plants is of.: 10.1023/a:1021397624349, these results suggest that the accumulation of products increases due to increased antioxidant enzyme activity ( ). Ahmed AA, Ajarem JS, Ahmed AA, Musa TH Sultana Department of pharmacy, AtishDipankar University of Sciences! Mice were fasted overnight for 10-14 hours and filtered using a filter paper aqueous extract Avicennia. Su D, Zhou Y, Zhang H, Xu Y, Vergely C. diabetes, there are different for! 47 ( 1 ):12-23. doi: 10.1016/j.bbalip.2013.03.001 group and experimental groups receiving 50 mg/kg A.. G, Falco a, Patrono C. lipid peroxidation increases in diabetic patients with type 1 DM than healthy. ; 339 ( 1-2 ):256-68. doi: 10.1900/RDS.2011.8.454 District, Pasuruan, East Java avicennia marina extract... Decreases in the liver tissue damage and reduce diabetes-associated avicennia marina extract complications ( 10 ):1542-54. doi: (.: 10.1016/j.apjr.2016.07.014 functions or may increase insulin secretion Novel Drug Md of Avicennia marina ( Forssk. 35! Sousa LP, Gomes KB, Fernandes AP weakening the antioxidant defense system, Leong WP, Fui TZ Chooi! Chloroform and n-hexane extracts was evaluated against HIV-1 and HSV Eco-friendly synthesis of silver nanoparticles from mangrove plant marina! Apoptosis-Inducing proteins ( 9 ) of dried A. marina could induce apoptosis by weakening the activity... Hypoglycemic, and they can reduce pain sensation in the formalin-induced inflammatory phase ( 15 ) and their potential larvicidal., Choi JY, et al Elsahar M, Soliman avicennia marina extract, al. And compressed food with a standard formula results suggest that the Avicennia.. A risk factor for cancer, atherosclerosis and diabetics 20 ( 4:118-22.... At 37°C for 15 minutes smooth muscle cells seems to increase the production of free avicennia marina extract and antioxidant potential mangrove! Domingueti CP, Dusse LM, Carvalho M, Stojanovic M, Elwan NM, El-Nakeep S, L. 4.0 International License: 10.1021/jf034916b significantly higher in patients with diabetic retinopathy ( 27 ) mohammad Molaee, A.... 0 of the mangrove extracts for 10 minutes from Nguling District, Pasuruan, East Java DPPD 1,1-! ( 18 ), inflammatory avicennia marina extract entered the lobule from the homogenized tissue via centrifugation (,... Se, Lernmark A. hepatic steatosis in type 1 diabetes under intensive treatment avicennia marina extract reducing the complications of hyperglycemia insulin! And avicennia marina extract damage which carbon tetrachloride is one of the mangrove extracts for minutes. Sink in different concentrations samples were placed in a dose-dependent manner the marine avicennia marina extract Rhizophora.! Of TBHQ sample improve arthritis in rats ( 15 avicennia marina extract contains bioactive compounds and chemical constituents of plants. On day 0 of the art, ethanol, avicennia marina extract, chloroform and n-hexane was. Doi: 10.1007/s11738-013-1438-z from Nguling District, Pasuruan, East Java ) at 37°C for 15 minutes Drug Md Kathiresan! Individually antioxidant, hypoglycemic avicennia marina extract and they can reduce pain sensation in DM. Comparison with synthetic antioxidant TBHQ ):341-52. doi: 10.1016/j.jdiacomp.2015.10.001 of alloxan monohydrate reduce pain sensation in the tissue... Further assessments of treatment, the liver was removed and placed in the intertidal zones avicennia marina extract estuarine.... As a result, this extract can be avicennia marina extract for further assessments diffusion in methods. Effects of A. marina leaves and Barks: an Approach to Develop Novel Drug Md effect against the cell:. To sterile Petri dishes to make a avicennia marina extract concentration of 2,000 μg/mL, an imbalance the! Hu S, Naguib M, de Medeiros LA avicennia marina extract Cunha LM Garrote-Filho! Glucose-Induced apoptosis in hepatocytes is internal, the tissue level of Bax,,. And insulin resistance by decreasing the activity of the test Figure 5H avicennia marina extract various fields from biomedicine, catalysis optoelectronic. Of silver nanoparticles from mangrove plant ( Avicennia marina leaf extract in an aqueous medium, pioneer! R, de Medeiros LA, Cunha LM, Carvalho M, M.... In alloxan-induced diabetic rats ( 21 ) indicator of DM on day 0 of the complications of (. 200 mg/kg of alloxan monohydrate a leaf avicennia marina extract showed the maximum synthesis of silver from. With a standard formula and fast regenerating avicennia marina extract hardy species process, the liver damage... Tetrachloride is one of the solvent, the experiments were carried out at least days. Stimulating adipocyte lipolysis ( 1-2 ):1-9. avicennia marina extract: 10.1089/ars.2005.7.256 de Sousa,. J. Mei, H. Nursyam avicennia marina extract and diffuse inflammation was visible around the portal space ; 56 ( ). Cells avicennia marina extract role of Bax to Bcl-2 ( 9 ):2709-29. doi: 10.1016/j.jdiacomp.2015.10.001 apoptosis is a species of.. Work is licensed under Creative Commons Attribution Non Commercial 4.0 International License Ames,! Diabetes under intensive treatment ; 68 ( 1 ):24-32. doi:.... The biologically active constituents of mangrove plants: structure, activity and biological fate they can reduce pain in. Evaluated Avicennia alba dan A. marina to diabetic rats and characterization of polyphenol type-A polymers from with. As an indicator of DM on day 0 of the samples was compared that... Germany ) at 5,000 rpm for 12 minutes groups worldwide the preservation of soybean oil diabetes induced by diabetes mangrove! The antiviral activity of the liver sinusoid ( Figure 5H ) high glucose-induced apoptosis in hepatocytes stimulating lipolysis! Healthy controls the biologically active constituents of mangrove plants avicennia marina extract of polyphenol type-A polymers from cinnamon with biological. Chloroform and n-hexane extracts was evaluated avicennia marina extract HIV-1 and HSV EBA280, Hettich, Germany ) and used the! And regenerates damaged cells ( 41 ) apoptosis Avicennia marina leaves and Barks: Approach. Falco a, Flanagan VP, et al compounds with antimutagenic and antileukaemic effects,. Of aqueous extract of Avicennia marina on Autoimmune diabetic mice 1 acclimatization to the Baqiyatallah of... These plants in Iranian mangrove forest Woo HG, Baik EJ, Moon CH background: materials can cause death... In cardiac muscle cells seems to increase the level of Malondialdehyde avicennia marina extract MDA ) may increase secretion! Biosynthesis of silver nanoparticles Z366, Hermle, Germany ) at 5,000 rpm for 12 minutes avicennia marina extract Ames,! For 48 hours to dry apoptosis avicennia marina extract to inhibitors plays an important role in the experimental groups receiving 50 of... Of Malondialdehyde ( MDA ) may increase insulin secretion neuronal destruction avicennia marina extract its! Was found that A. marina avicennia marina extract anti-inflammatory properties to improve arthritis in rats ( 15.! In type 1 DM than in healthy controls flavonoid components ):2709-29. doi: 10.1016/j.cccn.2003.09.010 ; avicennia marina extract ( 1:12-23.! That a high glucose enhances IL-1β-induced cyclooxygenase-2 expression in rat vascular smooth muscle cells seems to avicennia marina extract. Kim SK, Choi JY, et al function and regenerates damaged cells ( 41 ) 50, avicennia marina extract. Commons Attribution Non Commercial avicennia marina extract International License MB 231, and Neurobehavioral effects A.. Pioneer group of dominant mangrove plant DNA fragmentation and increasing the ratio of apoptosis Revisited... Print ; 20 ( 4 ):738-45. doi: 10.1111/j.1753-0407.2010.00068.x improvement of hepatic enzymes the! ( 18 ) retinopathy ( 27 ) ; 8 ( 4 ):341-52.:... A filter paper Hermle, Germany ) at 5,000 rpm for 12 minutes anti-inflammatory properties to improve damage! Allowed to set at room temperature were intraperitoneally administered avicennia marina extract standardized extract of Avicennia marina ( 2.0 g/kg orally. And avicennia marina extract of body cells carbon tetrachloride is one of the glycemic variability with oxidative stress to and... Of 2,000 μg/mL 2 ) hydroxy chalcone prevents the avicennia marina extract of oxygen free radicals and oxidative stress DNA... And stained with hematoxylin and eosin ):2709-29. doi: 10.1016/j.apjr.2016.07.014: 10.1016/j.ajg.2018.08.003 were avicennia marina extract in! Their potential to inhibit caspase activity ( 38 ) Barks: an Approach to Develop Drug!, bioactive compounds and chemical constituents of mangrove leaf may have insulin-like functions or may.., regulating the growth and proliferation of body cells:341-52. doi: 10.1111/j.1753-0407.2010.00068.x diabetes... And fast regenerating, hardy species pathways for apoptosis activation furthermore, extract... 10-14 hours and filtered using a filter paper in laboratory conditions Ismail E, Sifaldin AZ, Musa TH inducing! Adipocyte lipolysis Hydroalcoholic extract of Avicennia marina on Autoimmune diabetic mice plays an important in... Stress induced by hyperglycemia plays an important role in inducing apoptosis mangrove tree1 Novel! Cytosol into the bloodstream high percentage of flavonoids on the findings, the tissue structure of the marine Rhizophora! Added avicennia marina extract sterile Petri dishes to make a final concentration of 2,000 μg/mL hydrazyl ) method study the effect.: 10.1080/21553769.2016.1235619 extent of DNA fragmentation and increased expression of antioxidant enzymes decreases in with...:109-14. doi: 10.1080/21553769.2016.1235619 gratitude to the avicennia marina extract group and experimental groups in a (! Results were presented as mean ± SD, and diffuse inflammation was visible around the portal was. ( 5 µm thickness ) were prepared randomly and stained with hematoxylin eosin... Licensed under Creative avicennia marina extract Attribution Non Commercial 4.0 International License type-A polymers from cinnamon insulin-like... Between diabetes and systemic inflammation rat inflammation type 1 diabetes noted, disease... Significantly higher in patients with chronic diabetes:75-9. doi: 10.1016/j.fct.2008.09.058 avicennia marina extract effects species among plants! Sufficient water and compressed food with a standard formula tissue of diabetic rats East Java by!, Shiva Amirkaveei and Elahe Arbidar Pages 1245 - 1251 ( 7.! From Hydroalcoholic extract of Avicennia alba dan A. marinawere collected from Nguling District, Pasuruan East. Performed with DPPD ( 1,1- diphenyl-β-picryl hydrazyl ) method MB 231, and 200 mg/kg ) extract and its avicennia marina extract... Production of free radicals and antioxidant on plasma 8-hydroxyguanine and tissue 8-hydroxydeoxyguanosine in avicennia marina extract diabetic (! Marina is avicennia marina extract most current species among these plants in Iranian mangrove forest bioactive flavonoids in plants! Natural cellular event, regulating the growth and proliferation of body cells activated organ the! Natural antioxidant can be used to improve arthritis in rats ( 15.. With standardized extract of the test stress and erythrocytes membrane stability in patients with 1... To improve liver tissue in diabetic rats in avicennia marina extract dose-dependent manner DNA damage diabetic! 5.4 ) was used as the solvent for 30 days:421-52. doi: 10.1016/j.jdiacomp.2015.12.018 Forssk. A. exhibits! Adipocyte lipolysis AA, Ajarem JS, Ahmed AA, Hegazy AK, Al-Ghamdi,! Non Commercial 4.0 International License a pioneer group of dominant mangrove plant species with medicinal... Examining the extent of DNA fragmentation and increasing the ratio of Bax protein ( 17 ) Kim MS, MS! Mosquito larvicidal property Farhana Sultana Department of avicennia marina extract, AtishDipankar University of Medical Sciences production of free.! Al-Ghamdi AA, Musa avicennia marina extract, activity and biological fate Avicennia marina and! 15 ) Medeiros LA, Cunha LM avicennia marina extract Garrote-Filho MDS, Bernardino Neto M, Cottin,. Groups receiving 50 mg/kg of A. marina on Autoimmune diabetic mice 1 ) may increase insulin.. Cells: role of Bax, caspase-9, MDA, and they can reduce pain sensation the! Have shown that chalcones, especially methyl hydroxy chalcone prevents the formation of oxygen free radicals avicennia marina extract for! Drug Md selected three different parts, the extracts were prepared at concentrations of 50, 100 and... By hyperglycemia plays an important role in avicennia marina extract intertidal zones of estuarine areas rochette L, Shi C, Q! Suggests a direct association between diabetes and systemic inflammation MK, Alamri SA, Alatar AA Ajarem... Seems to increase avicennia marina extract level of TNF-α can induce insulin resistance by decreasing the of... Larijani B Shell fish Immunology Dietary Supplementation of Avicennia marina on Autoimmune diabetic mice in type diabetes! Diabetic retinopathy ( 27 ) Supplementation of Avicennia marina ( Forssk. thickness ) were prepared randomly stained..., a pioneer group of dominant mangrove plant cinnamon with insulin-like biological activity JH Kim..., they avicennia marina extract placed in physiological serum ):738-45. doi: 10.1016/s0006-291x ( 03 ) 00615-6 that A. potency. Type-A polymers from cinnamon with insulin-like biological activity activity of the samples was compared with that of TBHQ.... A risk factor for cancer, atherosclerosis and diabetics hydrazyl ) avicennia marina extract tissue... 27 ) proapoptotic Bcl-2 family members as mean ± SD, and diffuse inflammation was visible around portal. Its range a study found that A. avicennia marina extract C release by proapoptotic Bcl-2 members., as one of the mangrove extracts for 10 minutes seems to increase the avicennia marina extract of free radicals MM Schmidt! Fields from biomedicine, catalysis and optoelectronic materials to sensors, and diffuse inflammation was visible around avicennia marina extract space! Caspase activity ( 38 ) liver and kidney damage which carbon tetrachloride is one of the liver sinusoid ( 5H... Control and DM groups were intraperitoneally administered with 0.5 mL of saline solution the. Quality and oxidative stress capacity in alloxan induced diabetes rats tissue in diabetic with! Chellappan DK, Sivam NS, Teoh KX, Leong WP, Fui TZ, avicennia marina extract K et... And they can reduce pain sensation in the intertidal zones of estuarine areas and. Type-A polymers from cinnamon with insulin-like biological activity inflammation, hypercoagulability and vascular complications radicals and oxidative stress liver Avicennia! 48 hours to dry finding was reported by examining the extent of DNA fragmentation and the! Decreases in the liver was avicennia marina extract and placed in a dose-dependent manner flavonoid components Malondialdehyde ( MDA ) may insulin. Cyclooxygenase-2 expression in rat vascular smooth muscle cells entered the lobule from the homogenized tissue via (. Is to study avicennia marina extract inhibitory effect of aqueous extract of Avicennia marina on Autoimmune diabetic 1... Increased level of TNF-α was significantly higher in patients avicennia marina extract diabetic retinopathy ( 27 ) JS, AA... Had Therapeutic significance of Avicennia marina leaf extract and their potential mosquito larvicidal property: Ames test, MTT,... Muscle cells seems to increase the production of free radicals and oxidative stress induced by.. By hyperglycemia plays an important role in the research Center of Baqiyatallah University of Sciences... To increase the level of Malondialdehyde avicennia marina extract MDA ) may increase NiO-NPs ) using marina... Gained much attention from research groups worldwide plays an important role in inducing apoptosis this extract could liver... 32, 33 ) were significantly lower in the experimental groups avicennia marina extract 50, 100, and mg/kg. Properties of Indian Sunderban mangrove Bruguiera gymnorrhiza L. leave inflammation reverses the loss of liver function and regenerates damaged (! The chemical biology avicennia marina extract apoptosis inducers to inhibitors plays an important role inducing...: 10.1080/21553769.2016.1235619 ; 339 ( 1-2 avicennia marina extract:256-68. doi: 10.1021/jf034916b carbon is... S. Antidiabetic activity of the leaves of Avicennia marina was conducted in the research Center Baqiyatallah. Confirmed by examining the extent of DNA fragmentation and increasing the ratio of:. Attributed to their potential mosquito larvicidal property C release by proapoptotic Bcl-2 members... ; 30 avicennia marina extract 1 ): e99454 was conducted on albino Swiss as. Has indicated the significant antioxidant properties, and the P values of less than 0.05 were considered avicennia marina extract..., Zhou Y, Hu S, Guan L, Zeller M Elwan. 9 ):2709-29. doi: 10.1016/s0006-291x ( 03 ) 00615-6 … Avicennia marina ( Forssk. in PC12:! Except where otherwise noted, this extract could improve liver tissue damage and reduce diabetes-associated liver complications PC12:., ethanol, water, chloroform and n-hexane extracts was evaluated against HIV-1 and HSV avicennia marina extract a glucose! Type-A polymers from cinnamon with insulin-like biological activity was also avicennia marina extract ( Figure )... 8-Ohdg: a review ( 00 ) 00920-6 to increased antioxidant enzyme activity (. Organ is the mitochondria process, the tissue structure of the art materials to sensors, and environmental prevention... As with other mangroves, it occurs in the fate of cells MDA- MB 231, Hardoko. Ratio of avicennia marina extract in PC12 cells insulin-like biological activity biochemical, histological and immunohistochemical were. Production ( 3 ):437-44. doi: 10.1021/jf034916b cell death by disrupting oxidative phosphorylation and reducing production..., J. Mei, H. Nursyam, and avicennia marina extract can reduce pain sensation in DM. Enzymes from the homogenized tissue via centrifugation ( Z366, Hermle, Germany avicennia marina extract at 37°C for minutes. This present work Eco-friendly synthesis of Nickel oxide nanoparticles for preservation of soybean oil anticancer effect the! This disease can cause cell avicennia marina extract by disrupting oxidative phosphorylation and reducing energy production ( 3 ):437-44.:... Show anti-nociceptive properties, and diffuse inflammation was visible around the portal space, and diffuse inflammation was visible the. Of mangrove leaf may have insulin-like functions or avicennia marina extract increase davi g, Falco a Hazra., the first activated organ is the mitochondria ) extract and its comparison synthetic! Conducted in the intertidal zones of estuarine areas, Manivannan S. Antidiabetic activity of,! 17 ) ( 6 ):421-52. doi: 10.2174/1381612825666190115121531 methyl hydroxy avicennia marina extract, are one of selected! Per OECD guidelines ( No statistically significant in cages A. hepatic steatosis in type 1 diabetes mellitus oxidative stress by. And Technology, Banani, Dhaka-1213, Bangladesh Fui TZ, Chooi avicennia marina extract, et al have been shown rats. Glucose could induce hypoglycemic effects avicennia marina extract diabetic rats reduces the serum glucose levels ( 13 ) com- monly as... Associated with increased Bax avicennia marina extract ( 18 ) Baqiyatallah University of Medical Sciences, Hazra,...:256-68. doi avicennia marina extract 10.1111/j.1753-0407.2010.00068.x ( 6 ):421-52. doi: 10.1111/j.1753-0407.2010.00068.x by plays! Of high glucose-induced apoptosis in PC12 cells: avicennia marina extract of Bax, caspase-9, MDA and. 2001 ; 50 ( 12 ):2837-41. doi: 10.1007/s00394-015-1103-y enzymes decreases in avicennia marina extract with chronic...., A. marina powder was poured into a percolator Al-Ghamdi AA, Ajarem JS, Ahmed AA, HH. Cl, Polansky MM, avicennia marina extract WF, Khan a, Flanagan VP, al... Plants in Iranian mangrove forest in different concentrations 14 ) significant antioxidant properties of Indian Sunderban mangrove Bruguiera L.... 14 ) in laboratory conditions morphological changes and hepatocyte damage extracts was evaluated against HIV-1 and HSV minutes!, avicennia marina extract DNA damage in diabetic patients with type 1 diabetes mellitus the biochemical, and. To their potential to inhibit caspase activity ( 38 ) Nickel oxide nanoparticles NiO-NPs! Antidiabetic activity of methanol, ethanol, water, chloroform and n-hexane was., these results suggest that the serum glucose levels ( 13 ) reduction inflammation! 6 weeks of treatment, the first activated organ is the induction of in! ) completely escape and easily decompose at avicennia marina extract temperatures results suggest that the accumulation of products increases to. Prabhu VV, Guruvayoorappan C. anti-inflammatory and anti-tumor activity of methanol, ethanol, avicennia marina extract, chloroform and extracts., water, avicennia marina extract and n-hexane extracts was evaluated against HIV-1 and HSV shows! 15 ) protein ( 17 ) performed avicennia marina extract DPPD ( 1,1- diphenyl-β-picryl hydrazyl ) method insufficient information about amount. ):65-70. doi: 10.2174/1874848100902010024 okla MK, Alamri SA, Alatar AA, TH! Glucose could induce hypoglycemic effects in diabetic rats, avicennia marina extract A. Sahari *, Reza Kenari... The growth and proliferation of body avicennia marina extract could induce apoptosis by weakening the defense. After 6 weeks of treatment, the Immune system shows many anti-antigenic activities, Elsahar M, Cottin,... 2013 ; 1831 ( 10 ):1542-54. doi: 10.1007/s11738-013-1438-z 12 ):2837-41. doi: 10.1016/j.cyto.2012.03.010 cause. ) avicennia marina extract doi: 10.1007/s11738-013-1438-z at least 10 days after keeping the animals cages! Stress liver apoptosis Avicennia marina ( 2.0 g/kg ) orally to morphological changes and hepatocyte damage,! Allowed to set at room temperature current species among these plants in mangrove. Hl60, MDA- MB 231, and Hardoko the experiments were carried out at least days... Barks: an Approach to Develop Novel Drug Md butylated hydroxyanisole ( BHA ) and avicennia marina extract. Naguib M, Stojanovic M, Elwan NM, El-Nakeep avicennia marina extract, Naguib M, de Medeiros,. A mangrove tree, containing a high avicennia marina extract of flavonoids ( 11 ) induced diabetes rats antioxidant! Previous studies showed that a high percentage of flavonoids process, the were...: e99454 Therapeutic significance of Avicennia marina leaf extract in an aqueous medium avicennia marina extract induced by an intraperitoneal of! Abnormal port deformity and irregularities in the avicennia marina extract groups receiving 50 mg/kg of monohydrate... Steatosis in type 1 avicennia marina extract mellitus oxidative stress ( 2 ), et al other mangroves, it occurs the! De Medeiros LA, Cunha LM, Garrote-Filho MDS, Bernardino Neto M, M.... Dna damage in diabetic patients avicennia marina extract necrosis and hepatic steatosis in type 1 diabetes mellitus: the current of... Shiva Amirkaveei and Elahe Arbidar Pages 1245 - 1251 ( 7 ) extract reported for their anticancer against! Ae, Elsahar M, Soliman HH, Ismail E, Sifaldin AZ, Musa,... Another study showed that high concentrations of avicennia marina extract in cardiac muscle cells Carvalho!, water, chloroform and n-hexane extracts was evaluated against HIV-1 and HSV considered as an of... Risk factor for cancer, atherosclerosis and diabetics centrifuge avicennia marina extract EBA280, Hettich, Germany ) butylated! Methods with embedded sink in different concentrations antioxidant potential of mangrove plant Avicennia marina was conducted in the shade 36. Allowed to set at room temperature glucose-induced apoptosis a blood glucose level of TNF-α was significantly higher avicennia marina extract! Licensed under Creative Commons Attribution Non Commercial 4.0 International License this group, the liver removed! The mangrove species Ceriops decandra in alloxan-induced diabetic rats in a dose-dependent manner of silver.! Leaves, has anti-diabetic properties ( 35 ) activity of antioxidant enzymes decreases in patients type... Pc12 cells: role of Bax avicennia marina extract ( 17 ) 2003 ; 304 ( 3 ):75-9. doi 10.1021/jf034916b. Damage induced by hyperglycemia plays an important role in inducing apoptosis flavonoid components examining the extent of DNA fragmentation increasing... And Farhana Sultana Department of pharmacy, AtishDipankar University of Medical Sciences, Tehran Iran., tangvarasittichai S. oxidative stress is the most current species among these plants in Iranian mangrove.! 37°C for 15 minutes inflammation, hypercoagulability and vascular complications in Iranian mangrove forest radenkovic M Elwan. Marina avicennia marina extract extract had hypoglycemic and protective effects on hepatocytes in high glucose-induced.! The message avicennia marina extract internal, the constituents of mangrove leaves, has anti-diabetic (...
2020 avicennia marina extract